Linked Life Data

16156047

Source:http://linkedlifedata.com/resource/pubmed/id/16156047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-9-8
pubmed:abstractText
This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October, 2004. Chronic alcoholism follows a fluctuating course, which provides a naturalistic experiment in vulnerability, resilience, and recovery of human neural systems in response to presence, absence, and history of the neurotoxic effects of alcoholism. Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior. Specifically, alcohol dependence is characterized by a neuropsychological profile of mild to moderate impairment in executive functions, visuospatial abilities, and postural stability, together with relative sparing of declarative memory, language skills, and primary motor and perceptual abilities. Recovery from alcoholism is associated with a partial reversal of CNS deficits that occur in alcoholism. The reversal of deficits during recovery from alcoholism indicates that brain structure is capable of repair and restructuring in response to insult in adulthood. Indirect support of this repair model derives from studies of selective neuropsychological processes, structural and functional neuroimaging studies, and preclinical studies on degeneration and regeneration during the development of alcohol dependence and recovery form dependence. Genetics and brain regional specificity contribute to unique changes in neuropsychology and neuroanatomy in alcoholism and recovery. This symposium includes state-of-the-art presentations on changes that occur during active alcoholism as well as those that may occur during recovery-abstinence from alcohol dependence. Included are human neuroimaging and neuropsychological assessments, changes in human brain gene expression, allelic combinations of genes associated with alcohol dependence and preclinical studies investigating mechanisms of alcohol induced neurotoxicity, and neuroprogenetor cell expansion during recovery from alcohol dependence.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0145-6008
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1504-13
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16156047-Adult, pubmed-meshheading:16156047-Alcoholic Intoxication, pubmed-meshheading:16156047-Alcoholism, pubmed-meshheading:16156047-Brain Mapping, pubmed-meshheading:16156047-DNA Repair, pubmed-meshheading:16156047-Ethanol, pubmed-meshheading:16156047-Gene Expression Regulation, pubmed-meshheading:16156047-Humans, pubmed-meshheading:16156047-Magnetic Resonance Imaging, pubmed-meshheading:16156047-Memory, Short-Term, pubmed-meshheading:16156047-Motivation, pubmed-meshheading:16156047-Nerve Degeneration, pubmed-meshheading:16156047-Nerve Regeneration, pubmed-meshheading:16156047-Neurons, pubmed-meshheading:16156047-Neuropsychological Tests, pubmed-meshheading:16156047-Orientation, pubmed-meshheading:16156047-Receptors, GABA-A, pubmed-meshheading:16156047-Substance Withdrawal Syndrome
pubmed:year
2005
pubmed:articleTitle
Alcoholic neurobiology: changes in dependence and recovery.
pubmed:affiliation
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599-7178, USA. ftcrews@med.unc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Clinical Conference, Research Support, N.I.H., Extramural