Source:http://linkedlifedata.com/resource/pubmed/id/16155845
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2005-9-12
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| pubmed:abstractText |
The serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from an impaired cognitive performance. This is made evident after administration of 5-HT(2A/2C), and 5-HT4 receptor agonists, or 5-HT1A, 5-HT3 and probably 5-HT1B receptor antagonists. These serotonin receptor subtypes are localized on 'cognitive' pathways, with the hippocampus and frontal cortex as the main target structures. A better understanding of the role played in cognition by these and other serotonin receptor subtypes is likely to result from the recent availability of highly specific ligands such as 5-HT1A, 5-HT1B, and 5-HT2A receptor antagonists, and new molecular tools such as gene knock-out mice, especially inducible mice for which the genetic alteration can be restricted both temporally and anatomically.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1369-7056
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
426-37
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| pubmed:year |
1999
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| pubmed:articleTitle |
Serotonin receptors and cognitive behaviour--an update.
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| pubmed:affiliation |
Centre National de la Recherche Scientifique, UMR 5807, Université de Bordeaux I, Avenue des Facultés, 33405 Talence Cedex, France. buhot@neurocog.u-bordeaux.fr
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| pubmed:publicationType |
Journal Article
|