Linked Life Data

16154938

Source:http://linkedlifedata.com/resource/pubmed/id/16154938

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-9-12
pubmed:abstractText
Changes in gene expression associated with different forms of synaptic plasticity in rat hippocampus were investigated. Microarray analysis revealed differential expression of hundreds of genes 30 min after synaptic or antidromic stimulation in different patterns. Results of selected genes were verified by LightCycler RT-PCR. Synaptic activation in a theta burst protocol, which induced long-term potentiation (LTP), increased the mRNA abundance of BDNF-exon 1, but antidromic stimulation in the presence of CNQX, APV, and MCPG (to block glutamatergic synapses) decreased the level of mRNA of this transcript, as did 1 Hz synaptic stimulation. The opposite regulation of this BDNF transcript after firing of the postsynaptic neuron, coincidently or uncorrelated with synaptic firing, is consistent with the effects of BDNF on synaptic transmission, suggesting possible involvement in strengthening and weakening CA1 synapses after correlated versus uncorrelated firing of the postsynaptic neurons with its synaptic inputs. Possible involvement of transcriptional regulation of BDNF in the conversion of early-phase LTP to late-phase LTP are discussed in the context of previous studies by Dudek & Fields (Proc. Natl. Acad. Sci. USA 99: 3962-3967) showing that this conversion can be induced by antidromic stimulation of CA1 neurons in the absence of excitatory synaptic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1048
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-71
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Gene expression in the conversion of early-phase to late-phase long-term potentiation.
pubmed:affiliation
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article