Source:http://linkedlifedata.com/resource/pubmed/id/16154745
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
2005-10-5
|
| pubmed:abstractText |
Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase in oral bioavailability over the parent drug meptazinol in rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4953-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16154745-Animals,
pubmed-meshheading:16154745-Biological Availability,
pubmed-meshheading:16154745-Coumarins,
pubmed-meshheading:16154745-Drug Design,
pubmed-meshheading:16154745-Meptazinol,
pubmed-meshheading:16154745-Molecular Structure,
pubmed-meshheading:16154745-Prodrugs,
pubmed-meshheading:16154745-Rats
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|