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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2005-9-26
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pubmed:abstractText |
The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4717-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16153835-Antineoplastic Agents,
pubmed-meshheading:16153835-Aspergillus fumigatus,
pubmed-meshheading:16153835-Biological Agents,
pubmed-meshheading:16153835-Chitinase,
pubmed-meshheading:16153835-Crystallography, X-Ray,
pubmed-meshheading:16153835-Kinetics,
pubmed-meshheading:16153835-Models, Molecular,
pubmed-meshheading:16153835-Peptides, Cyclic,
pubmed-meshheading:16153835-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.
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pubmed:affiliation |
Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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