Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-10-24
pubmed:abstractText
Neural stem cells in the adult subventricular zone and dentate gyrus might be utilized to replace lost neurons in neurological disorders. The development of treatments would be facilitated by identifying the mechanisms that contribute to functional neurogenesis in adult animals. This review focuses on the emerging view that localized and overlapping pathways of growth factors, metalloproteases, neurotransmitters and hormones regulate different aspects of neurogenesis within the neurogenic niches. Neuroblast migration is precisely regulated by cooperation between several repellants, attractants and guidance molecules that are located within specific CNS regions. Further elucidation of crucial molecular regulators and integration of their signaling cascades should lead to more rational and effective approaches to harness the exciting phenomenon of adult CNS neurogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
589-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Molecular regulation of adult CNS neurogenesis: an integrated view.
pubmed:affiliation
Kentucky Spinal Cord Injury Research Center, Department of Neurological Surgery, University of Louisville, Louisville, KY 40292, USA. theo.hagg@louisville.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't