Source:http://linkedlifedata.com/resource/pubmed/id/16153708
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-12-27
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pubmed:databankReference | |
pubmed:abstractText |
Interleukin-6 (IL-6) is a multifunctional cytokine that plays roles in regulating immune responses, acute phase reactions and hematopoiesis. IL-6 signaling is regulated by two receptors, a specific alpha chain (IL-6Ralpha) and a signal transducer, gp130. In this study, cDNA encoding the 445 amino acid propeptide of chicken IL-6Ralpha (chIL-6Ralpha) was identified. The predicted 445 amino acids showed approximately 40% sequence identity with mammalian homologues. In a domain search, chIL-6Ralpha had a signal peptide of 20 residues, an immunoglobulin-like (IG) domain of 71 residues and a fibronectin-type III (FN III) domain of 85 residues. On comparison with mammalian homologues, four conserved cysteine residues and the WSXWS motif were observed in the N- and C-terminal regions of the FN III domain, respectively. Expression analysis revealed that chIL-6Ralpha is strongly expressed in liver and the chicken hepatoma cell line LMH. These findings indicate that the identified chicken cDNA sequence encodes a chIL-6Ralpha homologue.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0145-305X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-29
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16153708-Amino Acid Sequence,
pubmed-meshheading:16153708-Animals,
pubmed-meshheading:16153708-Base Sequence,
pubmed-meshheading:16153708-Chickens,
pubmed-meshheading:16153708-Cloning, Molecular,
pubmed-meshheading:16153708-Conserved Sequence,
pubmed-meshheading:16153708-DNA, Complementary,
pubmed-meshheading:16153708-Gene Expression Profiling,
pubmed-meshheading:16153708-Humans,
pubmed-meshheading:16153708-Molecular Sequence Data,
pubmed-meshheading:16153708-Organ Specificity,
pubmed-meshheading:16153708-Receptors, Interleukin-6,
pubmed-meshheading:16153708-Sequence Alignment
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pubmed:year |
2006
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pubmed:articleTitle |
Characterization and expression analysis of a chicken interleukin-6 receptor alpha.
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pubmed:affiliation |
Department of Immunobiology, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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