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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-9-12
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pubmed:abstractText |
Thoracic aortic aneurysmal diseases are characterized by degeneration of elastin within the aortic wall. Although proteinases, such as matrix metalloproteinase, appear to contribute to elastin degradation, little is known about the role of elastic fiber assembly in such diseases. Fibulin-5 is an extracellular protein that is expressed in the vascular basement membrane and regulates elastic fiber assembly by microfibril machinery. In this study, we examined whether thoracic aortic dissection (TAD) is associated with abnormal fibulin-5 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
pubmed-author:BartschHeatherH,
pubmed-author:CarterStacey ASA,
pubmed-author:ChenLiL,
pubmed-author:CoselliJoseph SJS,
pubmed-author:GanYehuaY,
pubmed-author:LeMaireScott ASA,
pubmed-author:OuHeshengH,
pubmed-author:ShenYing HYH,
pubmed-author:ThompsonRobert WRW,
pubmed-author:UtamaBudiB,
pubmed-author:WangXing LiXL,
pubmed-author:WangXinwenX,
pubmed-author:WilksJonathan AJA
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16153447-Aged,
pubmed-meshheading:16153447-Aneurysm, Dissecting,
pubmed-meshheading:16153447-Aorta, Thoracic,
pubmed-meshheading:16153447-Aortic Aneurysm, Thoracic,
pubmed-meshheading:16153447-Elastin,
pubmed-meshheading:16153447-Extracellular Matrix Proteins,
pubmed-meshheading:16153447-Female,
pubmed-meshheading:16153447-Gene Expression,
pubmed-meshheading:16153447-Humans,
pubmed-meshheading:16153447-Male,
pubmed-meshheading:16153447-Middle Aged,
pubmed-meshheading:16153447-RNA, Messenger,
pubmed-meshheading:16153447-Recombinant Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection.
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pubmed:affiliation |
Section of Adult Cardiac Surgery, the Texas Heart Institute at St. Luke's Episcopal Hospital, the Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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