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rdf:type |
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lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0331858,
umls-concept:C0391871,
umls-concept:C0439962,
umls-concept:C0441712,
umls-concept:C0680255,
umls-concept:C0700579,
umls-concept:C1283071,
umls-concept:C1527178,
umls-concept:C1704640,
umls-concept:C1705938,
umls-concept:C1706515,
umls-concept:C1963578,
umls-concept:C2603343
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pubmed:issue |
5
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pubmed:dateCreated |
2005-9-12
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pubmed:abstractText |
The aim of this work was to establish the diltiazem hydrochloride release mechanism from the chitosan-alginate matrix tablet (MCB/AS) and chitosan-carrageenan matrix tablet (MCS/CSI). The weight loss for MCS/CSI is mainly due to the weight loss of the matrix while for MCB/AS it is mainly due to the diltiazem hydrochloride released from the tablet. Using the Peppa's model the release order for MCS/CSI was n = 1.07 +/- 0.13 and for MCB/AS was n = 0.76 +/- 0.02. Thus, MCS/CSI has a transport mechanism, and for MCB/AS the drug release mechanism is a combined process of diffusion and relaxation. MCB/AS has an elastic modulus (G' = 10(5) Pa) one order of magnitude higher than MCS/CSI (G' = 10(4) Pa). MCB/AS is able to uptake solvent without disrupting the microstructure due to its high elastic modulus. Instead MCS/CSI showed a quick erosion process, which conducted to the tablet disintegration due to a fast solvent uptake process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alginates,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Chitosan,
http://linkedlifedata.com/resource/pubmed/chemical/Delayed-Action Preparations,
http://linkedlifedata.com/resource/pubmed/chemical/Diltiazem,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hexuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogels,
http://linkedlifedata.com/resource/pubmed/chemical/Solvents,
http://linkedlifedata.com/resource/pubmed/chemical/Tablets,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/alginic acid
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pubmed:status |
MEDLINE
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pubmed:issn |
1525-7797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2389-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16153073-Alginates,
pubmed-meshheading:16153073-Antihypertensive Agents,
pubmed-meshheading:16153073-Biocompatible Materials,
pubmed-meshheading:16153073-Carrageenan,
pubmed-meshheading:16153073-Chemistry, Pharmaceutical,
pubmed-meshheading:16153073-Chitosan,
pubmed-meshheading:16153073-Delayed-Action Preparations,
pubmed-meshheading:16153073-Diltiazem,
pubmed-meshheading:16153073-Drug Delivery Systems,
pubmed-meshheading:16153073-Glucuronic Acid,
pubmed-meshheading:16153073-Hexuronic Acids,
pubmed-meshheading:16153073-Hydrogels,
pubmed-meshheading:16153073-Kinetics,
pubmed-meshheading:16153073-Solubility,
pubmed-meshheading:16153073-Solvents,
pubmed-meshheading:16153073-Tablets,
pubmed-meshheading:16153073-Time Factors,
pubmed-meshheading:16153073-Water
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pubmed:articleTitle |
Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures.
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pubmed:affiliation |
Laboratory of Unit Operations, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Casilla 233, Santiago 1, Chile. ctapia@uchile.cl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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