Linked Life Data

16146794

Source:http://linkedlifedata.com/resource/pubmed/id/16146794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-9-8
pubmed:abstractText
The chemokines are a family of small molecules that mediate cell migration, activation, differentiation, angiogenesis, and perhaps other functions. The chemokines have been classified by their amino acid composition, functional activity, and receptor binding properties. The chemokines receptors are 7 transmembrane G proteins and there is considerable redundancy in ligand specificity. The role of chemokines in cancer is not well understood, but there is accumulating evidence that they play a major role in both tumorigenesis and the host immune response to tumors. Thus, chemokines and their receptors represent potential therapeutic targets for drug development. This article will briefly review the current understanding of chemokines biology of defined chemokines that are thought to be involved in tumor growth, metastasis, and the host immune response against cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1024-30
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Chemokines in tumor immunotherapy.
pubmed:affiliation
Department of Pathology, Columbia University, New York, NY 10032, USA.
pubmed:publicationType
Journal Article, Review