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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0031093,
umls-concept:C0031437,
umls-concept:C0086418,
umls-concept:C0205267,
umls-concept:C0441722,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1533691,
umls-concept:C1708715,
umls-concept:C2346689
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pubmed:dateCreated |
2005-9-8
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pubmed:abstractText |
Mechanical strain applied to bone leads to bone remodeling. In the oral cavity, it is unclear how such mechanical force applied to move teeth orthodontically induces alveolar bone remodeling. It is known that osteoclasts are the only cells that are responsible for bone resorption, while the formation and activity of osteoclasts are regulated by osteoblasts. So it is believed that osteoblasts play an important role not only in bone formation but in bone remodeling as well. Therefore, the purpose of this study was to examine the effect of mechanical force on human periodontal ligament (PDL) cells and whether they express osteoblastic characters in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11B protein, human
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pubmed:status |
MEDLINE
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pubmed:issn |
1093-4715
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
776-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16146769-Alkaline Phosphatase,
pubmed-meshheading:16146769-Bone Remodeling,
pubmed-meshheading:16146769-Cells, Cultured,
pubmed-meshheading:16146769-Down-Regulation,
pubmed-meshheading:16146769-Fibroblasts,
pubmed-meshheading:16146769-Glycoproteins,
pubmed-meshheading:16146769-Humans,
pubmed-meshheading:16146769-In Situ Hybridization,
pubmed-meshheading:16146769-Models, Statistical,
pubmed-meshheading:16146769-Osteoblasts,
pubmed-meshheading:16146769-Osteocalcin,
pubmed-meshheading:16146769-Osteoclasts,
pubmed-meshheading:16146769-Osteoprotegerin,
pubmed-meshheading:16146769-Periodontal Ligament,
pubmed-meshheading:16146769-Phenotype,
pubmed-meshheading:16146769-RNA, Messenger,
pubmed-meshheading:16146769-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:16146769-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16146769-Stress, Mechanical,
pubmed-meshheading:16146769-Time Factors,
pubmed-meshheading:16146769-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Human periodontal ligament cells express osteoblastic phenotypes under intermittent force loading in vitro.
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pubmed:affiliation |
Department of Orthodontics, Peking University School of Stomatology, Beijing, China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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