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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-9-8
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pubmed:abstractText |
Tacrolimus is an immunosuppressive drug with a narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp, encoded by MDR1) play an important role in the absorption and metabolism of tacrolimus. The objective of this study was to evaluate whether or not CYP3A5*1/*3 or MDR1 C3435T polymorphisms are associated with the tacrolimus concentration per dose.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0902-0063
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
638-43
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16146556-Absorption,
pubmed-meshheading:16146556-Adult,
pubmed-meshheading:16146556-Cytochrome P-450 CYP3A,
pubmed-meshheading:16146556-Cytochrome P-450 Enzyme System,
pubmed-meshheading:16146556-Dose-Response Relationship, Drug,
pubmed-meshheading:16146556-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16146556-Female,
pubmed-meshheading:16146556-Follow-Up Studies,
pubmed-meshheading:16146556-Genetic Markers,
pubmed-meshheading:16146556-Genotype,
pubmed-meshheading:16146556-Graft Rejection,
pubmed-meshheading:16146556-Humans,
pubmed-meshheading:16146556-Immunosuppressive Agents,
pubmed-meshheading:16146556-Kidney Transplantation,
pubmed-meshheading:16146556-Male,
pubmed-meshheading:16146556-Middle Aged,
pubmed-meshheading:16146556-P-Glycoprotein,
pubmed-meshheading:16146556-Polymorphism, Genetic,
pubmed-meshheading:16146556-Tacrolimus,
pubmed-meshheading:16146556-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation.
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pubmed:affiliation |
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
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pubmed:publicationType |
Journal Article,
Comparative Study
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