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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-9-12
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pubmed:abstractText |
Using radiography to assess the efficacy of a disease-modifying osteoarthritis (OA) drug on joint structure is challenging. Subchondral bone marrow abnormalities determined by magnetic resonance imaging (MRI) and urinary excretion of C-terminal crosslinking telopeptide of type II collagen (CTX-II) have recently been shown to be predictors of radiographic progression in patients with knee OA, suggesting that these may represent valuable biomarkers with increased sensitivity compared with findings on radiography. The aims of this investigation were to analyze, in patients with knee OA, whether the values associated with these 2 OA biomarkers can change within 3 months, and to investigate the relationships between bone marrow abnormalities and CTX-II.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2822-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16145678-Biological Markers,
pubmed-meshheading:16145678-Bone Marrow,
pubmed-meshheading:16145678-Collagen,
pubmed-meshheading:16145678-Collagen Type I,
pubmed-meshheading:16145678-Collagen Type II,
pubmed-meshheading:16145678-Female,
pubmed-meshheading:16145678-Femur,
pubmed-meshheading:16145678-Humans,
pubmed-meshheading:16145678-International Cooperation,
pubmed-meshheading:16145678-Knee Joint,
pubmed-meshheading:16145678-Longitudinal Studies,
pubmed-meshheading:16145678-Magnetic Resonance Imaging,
pubmed-meshheading:16145678-Male,
pubmed-meshheading:16145678-Middle Aged,
pubmed-meshheading:16145678-Osteoarthritis, Knee,
pubmed-meshheading:16145678-Pain Measurement,
pubmed-meshheading:16145678-Patella,
pubmed-meshheading:16145678-Peptides,
pubmed-meshheading:16145678-Severity of Illness Index,
pubmed-meshheading:16145678-Tibia
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pubmed:year |
2005
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pubmed:articleTitle |
Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study.
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pubmed:affiliation |
Synarc, Lyon, France. Patrick.Garnero@synarc.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
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