Linked Life Data

16144690

Source:http://linkedlifedata.com/resource/pubmed/id/16144690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2005-9-7
pubmed:abstractText
Hypoxic exposure of cells or organisms induces expression of a number of hypoxia responsive genes through the activation of the hypoxia-inducible factor-1 (HIF-1). One of the most prominent HIF-1 targets is erythropoietin that has beneficial effects on ischemia-related injury in the brain. Exposure to low environmental oxygen concentrations can be used as a preconditioning paradigm to protect cells or tissues against a variety of harmful conditions. Here, we summarize recent work on neuroprotection of retinal photoreceptors and ganglion cells induced by hypoxic preconditioning or by systemically elevated levels of Epo in mouse plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1084-9521
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration.
pubmed:affiliation
Laboratory of Retinal Cell Biology, University Eye Hospital Zurich, CH-8091 Zurich, Switzerland. cgrimm@opht.unizh.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't