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pubmed-article:16143535pubmed:abstractTextSome polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-alpha, IFN-alpha/gamma) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.lld:pubmed
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pubmed-article:16143535pubmed:articleTitleTannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells.lld:pubmed
pubmed-article:16143535pubmed:affiliationInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, Germany. kolpharm@zedat.fu-berlin.delld:pubmed
pubmed-article:16143535pubmed:publicationTypeJournal Articlelld:pubmed