Source:http://linkedlifedata.com/resource/pubmed/id/16143523
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
2005-9-26
|
| pubmed:abstractText |
A novel series of inhibitors of cancer cell proliferation, selective against p21 cell cycle checkpoint-disrupted cells vs. cells with intact p21 checkpoint, were identified by high-throughput screening. Optimization of both ends of the lead molecule to improve potency, using parallel synthesis and iterative design, is described. The 2-(1,4-dibenzodioxane)-substituted derivative 14 was identified as a highly selective and potent agent displaying an IC50 of 91 nM in the p21-deficient cell line.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4731-5
|
| pubmed:meshHeading |
pubmed-meshheading:16143523-Antineoplastic Agents,
pubmed-meshheading:16143523-Cell Line, Tumor,
pubmed-meshheading:16143523-Cell Proliferation,
pubmed-meshheading:16143523-Humans,
pubmed-meshheading:16143523-Inhibitory Concentration 50,
pubmed-meshheading:16143523-Pyrimidinones,
pubmed-meshheading:16143523-Structure-Activity Relationship,
pubmed-meshheading:16143523-Tubulin
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells.
|
| pubmed:affiliation |
Department of Exploratory Chemistry, Wyeth Research, Pearl River, NY 10965, USA. jenninl@wyeth.com
|
| pubmed:publicationType |
Journal Article
|