| pubmed-article:16143316 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16143316 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16143316 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16143316 | pubmed:dateCreated | 2005-9-19 | lld:pubmed |
| pubmed-article:16143316 | pubmed:abstractText | 2'-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-alpha-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-alpha-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-alpha-induced activation of NF-kappaB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-kappaB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-kappaB inactivation. | lld:pubmed |
| pubmed-article:16143316 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16143316 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16143316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143316 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16143316 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16143316 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:HongJin TaeJT | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:KwonByoung... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:ChungYoun... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:LeeJae... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:SonDong JuDJ | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:OhKi WanKW | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:LeeSeung HoSH | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:LeeChung... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:ChoiMyoung... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:LeeChong... | lld:pubmed |
| pubmed-article:16143316 | pubmed:author | pubmed-author:MoonDong... | lld:pubmed |
| pubmed-article:16143316 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16143316 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16143316 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:16143316 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16143316 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16143316 | pubmed:pagination | 1147-57 | lld:pubmed |
| pubmed-article:16143316 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:meshHeading | pubmed-meshheading:16143316... | lld:pubmed |
| pubmed-article:16143316 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16143316 | pubmed:articleTitle | Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. | lld:pubmed |
| pubmed-article:16143316 | pubmed:affiliation | College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju, South Korea. | lld:pubmed |
| pubmed-article:16143316 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16143316 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16143316 | lld:pubmed |
