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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-9-19
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pubmed:abstractText |
2'-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-alpha-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-alpha-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-alpha-induced activation of NF-kappaB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-kappaB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-kappaB inactivation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-2952
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pubmed:author |
pubmed-author:ChoiMyoung SukMS,
pubmed-author:ChungYoun BokYB,
pubmed-author:HongJin TaeJT,
pubmed-author:KwonByoung MogBM,
pubmed-author:LeeChong KilCK,
pubmed-author:LeeChung WooCW,
pubmed-author:LeeJae WoongJW,
pubmed-author:LeeSeung HoSH,
pubmed-author:MoonDong ChulDC,
pubmed-author:OhKi WanKW,
pubmed-author:SonDong JuDJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
70
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1147-57
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16143316-Apoptosis,
pubmed-meshheading:16143316-Blotting, Western,
pubmed-meshheading:16143316-Cell Line, Tumor,
pubmed-meshheading:16143316-Cinnamates,
pubmed-meshheading:16143316-Colonic Neoplasms,
pubmed-meshheading:16143316-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:16143316-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:16143316-Humans,
pubmed-meshheading:16143316-NF-kappa B,
pubmed-meshheading:16143316-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells.
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pubmed:affiliation |
College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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