Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-7-27
pubmed:abstractText
The ability to absorb exogenous pigments (Pgm+) has, until now, been considered an established virulence factor of Yersinia pestis, the causative agent of plague. This property correlates with the sensitivity to the bacteriocin pesticin (Psts). Both functions are chromosomally encoded. In the present study, using Hfr donors and isogenic Pgm-Psts and Pgm-Pstr mutants, these functions were shown to be determined by discrete but closely linked genes. These markers designated pgm and psn, respectively, were preliminarily located within a linkage group including 11 loci. It was also found that pigmentation is not essential for mouse virulence but is necessary for survival of Y. pestis in the flea, the plague vector. At the same time, conversion of an avirulent Pstr mutant to pesticin sensitivity restored some degree of virulence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0882-4010
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-86
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Analysis of Yersinia pestis chromosomal determinants Pgm+ and Psts associated with virulence.
pubmed:affiliation
Department of Genetics, Research Anti-Plague Institute Microbe, Saratov, Russia.
pubmed:publicationType
Journal Article