Linked Life Data

16142948

Source:http://linkedlifedata.com/resource/pubmed/id/16142948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2005-9-6
pubmed:abstractText
This paper reports the studies on micelle formation of new biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) (PEO-PHB-PEO) triblock copolymer with various PHB and PEO block lengths in aqueous solution. Transmission electron microscopy showed that the micelles took an approximately spherical shape with the surrounding diffuse outer shell formed by hydrophilic PEO blocks. The size distribution of the micelles formed by one triblock copolymer was demonstrated by dynamic light scattering technique. The critical micellization phenomena of the copolymers were extensively studied using the pyrene fluorescence dye absorption technique, and the (0,0) band changes of pyrene excitation spectra were used as a probe for the studies. For the copolymers studied in this report, the critical micelle concentrations ranged from 1.3 x 10(-5) to 1.1 x 10(-3) g/mL. For the same PEO block length of 5000, the critical micelle concentrations decreased with an increase in PHB block length, and the change was more significant in the short PHB range. It was found that the micelle formation of the biodegradable amphiphilic triblock copolymers consisting of poly(beta-hydroxyalkanoic acid) and PEO was relatively temperature-insensitive, which is quite different from their counterparts consisting of poly(alpha-hydroxyalkanoic acid) and PEO.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0743-7463
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8681-5
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Micellization phenomena of biodegradable amphiphilic triblock copolymers consisting of poly(beta-hydroxyalkanoic acid) and poly(ethylene oxide).
pubmed:affiliation
Institute of Materials Research and Engineering, National University of Singapore, 3 Research Link, Singapore 117602, Singapore. bielj@nus.edu.sg
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't