Linked Life Data

16142647

Source:http://linkedlifedata.com/resource/pubmed/id/16142647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-9-5
pubmed:abstractText
Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCgamma1 activity in vitro and the formation of inositol phosphates (IPt) in PLCgamma1-overexpressing NIH3T3 fibroblast cells (NIH3T3gamma1 cells). These flavonoids inhibited PLCgamma1 activity in a dose-dependent manner (IC (50) values ranged from 1.0 microg/mL to 35.0 microg/mL) with the exception of alpinumisoflavone ( 5). Also erysenegalensein D ( 2) and erysenegalensein N ( 3) showed inhibition of inositol phosphate formation in NIH3T3gamma1 cells with IC (50) values of 13.0 microg/mL and 10 microg/mL, respectively. Analyzing the relation of structure to activity, the number of prenyl groups and the hydroxylation of the prenyl groups were important factors for the inhibition of PLCgamma1 activity and of inositol phosphate formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0032-0943
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
780-2
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Phospholipase Cgamma1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis.
pubmed:affiliation
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejon, Korea.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't