| pubmed-article:16142327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C0596995 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16142327 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:16142327 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16142327 | pubmed:dateCreated | 2005-9-5 | lld:pubmed |
| pubmed-article:16142327 | pubmed:abstractText | Alveolar rhabdomyosarcoma (ARMS) cells express high levels of PAX3-FKHR and IGF-II. In this study, we have investigated the effects of PAX3-FKHR and IGF-II on the expression of muscle regulatory factors (myf5, MyoD and myogenin), and platelet derived growth factor-B (PDGF-B) and vascular endothelial growth factor (VEGF) in mouse C2C12 myoblasts in vitro. PAX3-FKHR induced cell cycling of C2C12 cells and promoted proliferation whilst blocking myogenesis. IGF-II inhibited their differentiation without influencing proliferation. Western blotting showed that PAX3-FKHR and IGF-II blocked the expression of myogenin and MyoD respectively. Since MyoD affects early myogenesis and myogenin controls terminal differentiation, a combination of PAX3-FKHR and IGF-II synergistically blocks myogenesis at several different stages in differentiation. We have also shown that the major survival and angiogenic cytokines, PDGF-B and VEGF, were induced by IGF-II and PAX3-FKHR respectively. A combination of PAX3-FKHR and IGF-II could synergistically up regulate the expression of PDGF-B and VEGF and stabilize their high expression levels. Our results suggest that high expression of PAX3-FKHR and IGF-II in ARMS synergistically play a key role in oncogenesis and tumour progression of ARMS. | lld:pubmed |
| pubmed-article:16142327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16142327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16142327 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16142327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16142327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16142327 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16142327 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:16142327 | pubmed:author | pubmed-author:WantDD | lld:pubmed |
| pubmed-article:16142327 | pubmed:author | pubmed-author:KumarSS | lld:pubmed |
| pubmed-article:16142327 | pubmed:author | pubmed-author:KumarPP | lld:pubmed |
| pubmed-article:16142327 | pubmed:author | pubmed-author:SlevinMM | lld:pubmed |
| pubmed-article:16142327 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16142327 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16142327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16142327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16142327 | pubmed:pagination | 1087-96 | lld:pubmed |
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| pubmed-article:16142327 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16142327 | pubmed:articleTitle | The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts. | lld:pubmed |
| pubmed-article:16142327 | pubmed:affiliation | Department of Biological Sciences, Manchester Metropolitan University, Manchester M1 5GD, UK. | lld:pubmed |
| pubmed-article:16142327 | pubmed:publicationType | Journal Article | lld:pubmed |
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