Linked Life Data

16140982

Source:http://linkedlifedata.com/resource/pubmed/id/16140982

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pubmed-article:16140982pubmed:abstractTextMicrophthalmia-associated transcription factor (MITF) M-form is a melanocyte-specific transcription factor that plays a key role in melanocyte development, survival, and differentiation. Here, we identified MITF as a new substrate of caspases and we characterized the cleavage site after Asp 345 in the C-terminal domain. We show that expression of a noncleavable form of MITF renders melanoma cells resistant to apoptotic stimuli, and we found that the C-terminal fragment generated upon caspase cleavage is endowed with a proapoptotic activity that sensitizes melanoma cells to death signals. The proapoptotic function gained by MITF following its processing by caspases provides a tissue-restricted means to modulate death in melanocyte and melanoma cells.lld:pubmed
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pubmed-article:16140982pubmed:articleTitleThe cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis.lld:pubmed
pubmed-article:16140982pubmed:affiliationINSERM U597, Biologie et Pathologie des cellules mélanocytaires: de la pigmentation cutanée aux mélanomes, Ligue Nationale contre le Cancer, Equipe labellisée 2001, 06107 NICE Cedex 2, France.lld:pubmed
pubmed-article:16140982pubmed:publicationTypeJournal Articlelld:pubmed
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