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rdf:type |
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lifeskim:mentions |
umls-concept:C0010656,
umls-concept:C0025201,
umls-concept:C0032214,
umls-concept:C0035820,
umls-concept:C0162638,
umls-concept:C0205224,
umls-concept:C0218694,
umls-concept:C0596311,
umls-concept:C0600138,
umls-concept:C1330957,
umls-concept:C1417172,
umls-concept:C1513095
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pubmed:issue |
17
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pubmed:dateCreated |
2005-9-5
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pubmed:abstractText |
Microphthalmia-associated transcription factor (MITF) M-form is a melanocyte-specific transcription factor that plays a key role in melanocyte development, survival, and differentiation. Here, we identified MITF as a new substrate of caspases and we characterized the cleavage site after Asp 345 in the C-terminal domain. We show that expression of a noncleavable form of MITF renders melanoma cells resistant to apoptotic stimuli, and we found that the C-terminal fragment generated upon caspase cleavage is endowed with a proapoptotic activity that sensitizes melanoma cells to death signals. The proapoptotic function gained by MITF following its processing by caspases provides a tissue-restricted means to modulate death in melanocyte and melanoma cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-10497301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-10673502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-10707962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-10898786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-11076759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-11929831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12032083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12086670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12093801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12473692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12655297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-12859621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-14632202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-14645519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15177886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15243584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15568981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15607961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15623583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-15716956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-8343963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-8707852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-8782819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9199364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9223672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9327738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9435230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9440696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9447965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9700169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9753675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16140982-9830058
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1980-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16140982-Animals,
pubmed-meshheading:16140982-Apoptosis,
pubmed-meshheading:16140982-Base Sequence,
pubmed-meshheading:16140982-Binding Sites,
pubmed-meshheading:16140982-Caspases,
pubmed-meshheading:16140982-Cell Line, Tumor,
pubmed-meshheading:16140982-Cells, Cultured,
pubmed-meshheading:16140982-DNA-Binding Proteins,
pubmed-meshheading:16140982-Humans,
pubmed-meshheading:16140982-Melanocytes,
pubmed-meshheading:16140982-Melanoma,
pubmed-meshheading:16140982-Melanoma, Experimental,
pubmed-meshheading:16140982-Mice,
pubmed-meshheading:16140982-Microphthalmia-Associated Transcription Factor,
pubmed-meshheading:16140982-Protein Processing, Post-Translational,
pubmed-meshheading:16140982-Protein Structure, Tertiary,
pubmed-meshheading:16140982-RNA, Small Interfering,
pubmed-meshheading:16140982-Substrate Specificity,
pubmed-meshheading:16140982-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis.
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pubmed:affiliation |
INSERM U597, Biologie et Pathologie des cellules mélanocytaires: de la pigmentation cutanée aux mélanomes, Ligue Nationale contre le Cancer, Equipe labellisée 2001, 06107 NICE Cedex 2, France.
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pubmed:publicationType |
Journal Article
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