Linked Life Data

16140970

Source:http://linkedlifedata.com/resource/pubmed/id/16140970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2005-9-5
pubmed:abstractText
Prostate cancer is the most common cancer in men in America. Currently, steroid receptor coactivators have been proposed to mediate the development and progression of prostate cancer, at times in a steroid-independent manner. Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR, RAC3, and TRAM-1) is a member of the p160 family of coactivators for nuclear hormone receptors including the androgen receptor. SRC-3 is frequently amplified or overexpressed in a number of cancers. However, the role of SRC-3 in cancer cell proliferation and survival is still poorly understood. In this study, we show that SRC-3 is overexpressed in prostate cancer patients and its overexpression correlates with prostate cancer proliferation and is inversely correlated with apoptosis. Consistent with patient data, we have observed that reduction of SRC-3 expression by small interfering RNA decreases proliferation, delays the G1-S transition, and increases cell apoptosis of different prostate cancer cell lines. Furthermore, with decreased SRC-3 expression, proliferating cell nuclear antigen and Bcl-2 expression, as well as bromodeoxyuridine incorporation in prostate cancer cells are reduced. Finally, knockdown of SRC-3 with inducible short hairpin RNA expression in prostate cancer cells decreased tumor growth in nude mice. Taken together, these findings indicate that SRC-3 is an important regulator of prostate cancer proliferation and survival.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7976-83
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16140970-Acetyltransferases, pubmed-meshheading:16140970-Animals, pubmed-meshheading:16140970-Cell Growth Processes, pubmed-meshheading:16140970-Cell Line, Tumor, pubmed-meshheading:16140970-Cell Survival, pubmed-meshheading:16140970-Down-Regulation, pubmed-meshheading:16140970-Histone Acetyltransferases, pubmed-meshheading:16140970-Humans, pubmed-meshheading:16140970-Male, pubmed-meshheading:16140970-Mice, pubmed-meshheading:16140970-Mice, Nude, pubmed-meshheading:16140970-Nuclear Receptor Coactivator 3, pubmed-meshheading:16140970-Oncogene Proteins, pubmed-meshheading:16140970-Prostate-Specific Antigen, pubmed-meshheading:16140970-Prostatic Neoplasms, pubmed-meshheading:16140970-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:16140970-RNA, Small Interfering, pubmed-meshheading:16140970-Trans-Activators
pubmed:year
2005
pubmed:articleTitle
SRC-3 is required for prostate cancer cell proliferation and survival.
pubmed:affiliation
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural