Linked Life Data

1614037

Source:http://linkedlifedata.com/resource/pubmed/id/1614037

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-7-24
pubmed:abstractText
Free Cd2+ uptake was determined by fluorescence techniques with the use of mag-fura-2 in single epithelial MDCK cells. Cytosolic Cd2+ increased in a time-dependent and concentration-dependent manner following the addition of cadmium to the external solution. The increment in cytosolic Cd2+ was greater in magnesium-depleted cells relative to normal cells. Uptake in normal and magnesium-depleted cells was inhibited by the channel antagonist, verapamil, and increased with the agonist, Bay K 8644. These studies indicate that free Cd2+ may exist in the cell cytosol and Cd2+ uptake is greater following magnesium-depletion. These data support the notion that magnesium may provide a cytoprotective effect in cadmium toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1237-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Free cadmium activity in renal epithelial cells is enhanced by Mg2+ depletion.
pubmed:affiliation
Department of Medicine, University of British Columbia, University Hospital, Vancouver, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't