| pubmed-article:16140291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C1540661 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:16140291 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16140291 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16140291 | pubmed:dateCreated | 2005-10-3 | lld:pubmed |
| pubmed-article:16140291 | pubmed:abstractText | lin-1 encodes an ETS domain transcription factor that functions downstream of a Ras/MAP kinase pathway mediating induction of the 1 degrees cell fate during vulval development in the C. elegans hermaphrodite. Mutants lacking lin-1 activity display a phenotype similar to that caused by mutations that constitutively activate let-60 Ras consistent with a model in which lin-1 is a repressor of the 1 degree fate whose activity is inhibited by phosphorylation by MPK-1 MAP kinase. Here, we show that, contrary the current model, lin-1 is required positively for the proper expression of several genes regulated by the pathway in cells adopting the 1 degrees cell fate. We show that the positive requirement for lin-1 is downstream of let-60 Ras and mpk-1 MAP kinase, and that it has a focus in the vulval precursor cells themselves. lin-1 alleles encoding proteins lacking a docking site for MPK-1 MAP kinase are defective in the positive function. We also show that lin-1 apparently has both positive and negative functions during the specification of the fates of other cells in the worm requiring Ras/MAP kinase signaling. | lld:pubmed |
| pubmed-article:16140291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16140291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16140291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16140291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16140291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16140291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16140291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16140291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16140291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16140291 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16140291 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:16140291 | pubmed:author | pubmed-author:TuckSimonS | lld:pubmed |
| pubmed-article:16140291 | pubmed:author | pubmed-author:TiensuuTeresa... | lld:pubmed |
| pubmed-article:16140291 | pubmed:author | pubmed-author:LarsenMorten... | lld:pubmed |
| pubmed-article:16140291 | pubmed:author | pubmed-author:VernerssonEmm... | lld:pubmed |
| pubmed-article:16140291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16140291 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16140291 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:16140291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16140291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16140291 | pubmed:pagination | 338-51 | lld:pubmed |
| pubmed-article:16140291 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16140291 | pubmed:meshHeading | pubmed-meshheading:16140291... | lld:pubmed |
| pubmed-article:16140291 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16140291 | pubmed:articleTitle | lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans. | lld:pubmed |
| pubmed-article:16140291 | pubmed:affiliation | Umeå Center for Molecular Pathogenesis, Umeå University, SE-901 87 Umeå, Sweden. | lld:pubmed |
| pubmed-article:16140291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16140291 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16140291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16140291 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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