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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-1
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pubmed:abstractText |
To assure drug safety, the investigation of the relationship between plasma concentration and drug-induced prolongation of the QT interval of the ECG is a challenge in drug discovery. For this purpose, dofetilide was utilized to demonstrate the benefits of characterizing the complete time course of concentrations and effect in conscious beagle dogs in the assessment of drug safety.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1056-8719
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-83
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pubmed:meshHeading |
pubmed-meshheading:16140023-Animals,
pubmed-meshheading:16140023-Anti-Arrhythmia Agents,
pubmed-meshheading:16140023-Dogs,
pubmed-meshheading:16140023-Drug Evaluation, Preclinical,
pubmed-meshheading:16140023-Female,
pubmed-meshheading:16140023-Heart Conduction System,
pubmed-meshheading:16140023-Infusions, Intravenous,
pubmed-meshheading:16140023-Long QT Syndrome,
pubmed-meshheading:16140023-Male,
pubmed-meshheading:16140023-Models, Biological,
pubmed-meshheading:16140023-Phenethylamines,
pubmed-meshheading:16140023-Sulfonamides,
pubmed-meshheading:16140023-Telemetry
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pubmed:articleTitle |
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
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pubmed:affiliation |
AstraZeneca R&D Södertälje, SE-151 85 Södertälje, Sweden. anna.ollerstam@astrazeneca.com
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pubmed:publicationType |
Journal Article
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