| pubmed-article:16138302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16138302 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:16138302 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16138302 | lifeskim:mentions | umls-concept:C0877853 | lld:lifeskim |
| pubmed-article:16138302 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:16138302 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:16138302 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16138302 | pubmed:dateCreated | 2005-9-12 | lld:pubmed |
| pubmed-article:16138302 | pubmed:abstractText | The ever-increasing cellular roles ascribed to RNA raise fundamental questions regarding how a biopolymer composed of only four chemically similar building-block nucleotides achieves such functional diversity. Here, I discuss how RNA achieves added mechanistic and chemical complexity by undergoing highly controlled conformational changes in response to a variety of cellular signals. I examine pathways for achieving selectivity in these conformational changes that rely to different extents on the structure and dynamics of RNA. Finally, I review solution-state NMR techniques that can be used to characterize RNA structural dynamics and its relationship to function. | lld:pubmed |
| pubmed-article:16138302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16138302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16138302 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16138302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16138302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16138302 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16138302 | pubmed:issn | 1439-4227 | lld:pubmed |
| pubmed-article:16138302 | pubmed:author | pubmed-author:Al-HashimiHas... | lld:pubmed |
| pubmed-article:16138302 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16138302 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:16138302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16138302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16138302 | pubmed:pagination | 1506-19 | lld:pubmed |
| pubmed-article:16138302 | pubmed:meshHeading | pubmed-meshheading:16138302... | lld:pubmed |
| pubmed-article:16138302 | pubmed:meshHeading | pubmed-meshheading:16138302... | lld:pubmed |
| pubmed-article:16138302 | pubmed:meshHeading | pubmed-meshheading:16138302... | lld:pubmed |
| pubmed-article:16138302 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16138302 | pubmed:articleTitle | Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy. | lld:pubmed |
| pubmed-article:16138302 | pubmed:affiliation | Department of Chemistry and Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109, USA. hashimi@umich.edu | lld:pubmed |
| pubmed-article:16138302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16138302 | pubmed:publicationType | Review | lld:pubmed |
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