Linked Life Data

16138302

Source:http://linkedlifedata.com/resource/pubmed/id/16138302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-9-12
pubmed:abstractText
The ever-increasing cellular roles ascribed to RNA raise fundamental questions regarding how a biopolymer composed of only four chemically similar building-block nucleotides achieves such functional diversity. Here, I discuss how RNA achieves added mechanistic and chemical complexity by undergoing highly controlled conformational changes in response to a variety of cellular signals. I examine pathways for achieving selectivity in these conformational changes that rely to different extents on the structure and dynamics of RNA. Finally, I review solution-state NMR techniques that can be used to characterize RNA structural dynamics and its relationship to function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1439-4227
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1506-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy.
pubmed:affiliation
Department of Chemistry and Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109, USA. hashimi@umich.edu
pubmed:publicationType
Journal Article, Review