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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-21
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pubmed:abstractText |
Hormone replacement therapy (HRT) is commonly prescribed to alleviate the climacteric symptoms of menopause. Recent findings from the Women's Health Initiative has raised questions about the routine use of HRT due to the increased observed incidence of cardiovascular disease and of breast and ovarian cancers in the treatment arm of the trial. In the general population, the association between HRT use and risk of ovarian cancer has not yet been resolved. This association has not been evaluated in BRCA1 or BRCA2 mutation carriers who face very high lifetime risks of both breast and ovarian cancers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0090-8258
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pubmed:author |
pubmed-author:AinsworthPeterP,
pubmed-author:GhadirianParvizP,
pubmed-author:IsaacsClaudineC,
pubmed-author:KarlanBethB,
pubmed-author:KotsopoulosJoanneJ,
pubmed-author:LubinskiJanJ,
pubmed-author:LynchHenry THT,
pubmed-author:MollerPalP,
pubmed-author:NarodSteven ASA,
pubmed-author:NeuhausenSusan LSL,
pubmed-author:RosenBarryB,
pubmed-author:SunPingP
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16137751-Aged,
pubmed-meshheading:16137751-Aged, 80 and over,
pubmed-meshheading:16137751-Case-Control Studies,
pubmed-meshheading:16137751-Cocarcinogenesis,
pubmed-meshheading:16137751-Estrogen Replacement Therapy,
pubmed-meshheading:16137751-Female,
pubmed-meshheading:16137751-Genes, BRCA1,
pubmed-meshheading:16137751-Genes, BRCA2,
pubmed-meshheading:16137751-Genetic Predisposition to Disease,
pubmed-meshheading:16137751-Germ-Line Mutation,
pubmed-meshheading:16137751-Humans,
pubmed-meshheading:16137751-Middle Aged,
pubmed-meshheading:16137751-Ovarian Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.
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pubmed:affiliation |
Centre for Research in Women's Health, 790 Bay Street, 7th Floor, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1N8.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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