Linked Life Data

16136542

Source:http://linkedlifedata.com/resource/pubmed/id/16136542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-9-6
pubmed:abstractText
In Israel, as in several countries of the Mediterranean basin, beta-thalassemia is frequent among Arabs, and many different mutations in the beta globin gene have been identified. In a single Arab village, three different thalassemia mutations, as well as the sickle-cell mutation, were characterized. Using genealogical data as well as the results of screening in the village population, we were able to demonstrate/speculate on how mutations were introduced into the village and how they later expanded. The sickle-cell mutation became particularly prevalent in the village as the result of a founder effect due to a preference for consanguineous marriages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1042-0533
pubmed:author
pubmed:copyrightInfo
Copyright 2005 Wiley-Liss, Inc
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
659-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Origin and expansion of four different beta globin mutations in a single Arab village.
pubmed:affiliation
Department of Community Genetics, Public Health Services, Health Ministry and Hebrew University, Jerusalem, Israel. joelz@cc.huji.ac.il
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't