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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-10-13
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pubmed:abstractText |
The monoclonal antibody D2-40 is a specific lymphatic endothelial markers and D2-40 staining have been applicable to evaluate lymphatic invasion in various malignant neoplasms. In the present study, we investigated lymph node micrometastasis determined by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) in all dissected lymph nodes obtained from 80 patients with node-negative gastric cancer, and analysed the relationship between micrometastasis and clinicopathological findings including lymphatic invasion of the resected primary tumour using D2-40 immunohistochemical staining. The incidence of micrometastasis determined by IHC and RT-PCR was 11.3% (nine out of 80) and 31.3% (25 out of 80), respectively. Although haematoxylin-eosin (HE) staining revealed lymphatic invasion in 11.3% (nine out of 80) of patients, D2-40 staining uncovered new invasion in 23.8% (19 out of 80) of patients. In the diagnosis of HE and D2-40 staining, the incidence of micrometastasis was significantly higher in patients with lymphatic invasion than in those without lymphatic invasion (P=0.0150 and P<0.0001, respectively). Micrometastasis correlated more closely with D2-40 than with HE staining. We demonstrated a high incidence of micrometastasis and lymphatic invasion and a correlation between them even in pN0 gastric cancer. When planning less invasive treatment, the presence of such occult cancer cells should be considered.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-10408868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-10421506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-10660756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-10761790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-11950918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-12075175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-12218087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-12576435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-14550948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-14597447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-14654901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-1558490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-7512130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-7530983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-7542169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-8076567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-8644003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-8869330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-9014686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-9070482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16136051-9217757
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-93
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pubmed:dateRevised |
2010-9-20
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pubmed:meshHeading |
pubmed-meshheading:16136051-Aged,
pubmed-meshheading:16136051-Aged, 80 and over,
pubmed-meshheading:16136051-Antibodies, Monoclonal,
pubmed-meshheading:16136051-Endothelium, Lymphatic,
pubmed-meshheading:16136051-Female,
pubmed-meshheading:16136051-Humans,
pubmed-meshheading:16136051-Immunoenzyme Techniques,
pubmed-meshheading:16136051-Lymph Nodes,
pubmed-meshheading:16136051-Lymphatic Metastasis,
pubmed-meshheading:16136051-Male,
pubmed-meshheading:16136051-Middle Aged,
pubmed-meshheading:16136051-Neoplasm Invasiveness,
pubmed-meshheading:16136051-Neoplasm Staging,
pubmed-meshheading:16136051-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16136051-Stomach Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer.
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pubmed:affiliation |
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. arigami@m.kufm.kagoshima-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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