Linked Life Data

16134929

Source:http://linkedlifedata.com/resource/pubmed/id/16134929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2005-9-1
pubmed:abstractText
Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivo biological activity of this interesting compound is also reported.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2623
pubmed:author
pubmed-author:AttarRicardoR, pubmed-author:BalasubramanianBaluB, pubmed-author:BalimanePraveenP, pubmed-author:BeaulieuFrancisF, pubmed-author:BrassilPatrickP, pubmed-author:CarboniJoanJ, pubmed-author:ChangChiehyingC, pubmed-author:ClarkeWendyW, pubmed-author:DellJanetJ, pubmed-author:EngGraceG, pubmed-author:EummerJeffreyJ, pubmed-author:FrennessonDavidD, pubmed-author:GottardisMarcoM, pubmed-author:HanselStevenS, pubmed-author:HurlburtWarrenW, pubmed-author:JacobsonBruceB, pubmed-author:KrishnananthanSubramaniamS, pubmed-author:LeeFrancis YFY, pubmed-author:LiAixinA, pubmed-author:LinTai-AnTA, pubmed-author:LiuPeiyingP, pubmed-author:OuelletCarlC, pubmed-author:SangXiaopengX, pubmed-author:SaulnierMark GMG, pubmed-author:StoffanKarenK, pubmed-author:SunYaxY, pubmed-author:VelaparthiUpenderU, pubmed-author:VyasDolatraiD, pubmed-author:WittmanMarkM, pubmed-author:WongHenryH, pubmed-author:YangZhengZ, pubmed-author:ZimmermannKurtK, pubmed-author:ZoecklerMaryM
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5639-43
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16134929-Animals, pubmed-meshheading:16134929-Antineoplastic Agents, pubmed-meshheading:16134929-Benzimidazoles, pubmed-meshheading:16134929-Biological Availability, pubmed-meshheading:16134929-Cell Line, Tumor, pubmed-meshheading:16134929-Crystallography, X-Ray, pubmed-meshheading:16134929-Drug Screening Assays, Antitumor, pubmed-meshheading:16134929-Haplorhini, pubmed-meshheading:16134929-Humans, pubmed-meshheading:16134929-Mice, pubmed-meshheading:16134929-Mice, Nude, pubmed-meshheading:16134929-Models, Molecular, pubmed-meshheading:16134929-Molecular Structure, pubmed-meshheading:16134929-Neoplasm Transplantation, pubmed-meshheading:16134929-Pyridines, pubmed-meshheading:16134929-Pyridones, pubmed-meshheading:16134929-Rats, pubmed-meshheading:16134929-Receptor, IGF Type 1, pubmed-meshheading:16134929-Receptor, Insulin, pubmed-meshheading:16134929-Structure-Activity Relationship
pubmed:year
2005
pubmed:articleTitle
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
pubmed:affiliation
Discovery Chemistry, Department of Metabolism and Pharmacokinetics, Department of Computer Aided Drug Design, and Department of Chemical Synthesis, Bristol-Myers Squibb Co, 5 Research Parkway, Wallingford, Connecticut 06492, USA. mark.wittman@bms.com
pubmed:publicationType
Journal Article