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rdf:type |
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lifeskim:mentions |
umls-concept:C0003392,
umls-concept:C0007600,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0034537,
umls-concept:C0038952,
umls-concept:C0086418,
umls-concept:C0153381,
umls-concept:C0285558,
umls-concept:C0334227,
umls-concept:C0442027,
umls-concept:C0596581,
umls-concept:C0812228,
umls-concept:C0879262,
umls-concept:C1314939,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1705328,
umls-concept:C1705341,
umls-concept:C1710082,
umls-concept:C2349975
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pubmed:issue |
2
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pubmed:dateCreated |
2005-8-30
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pubmed:abstractText |
To examine the effect of an oral fluoropyrimidine anti-cancer agent (S-1) on the radiosensitivity of a human oral cancer cell line with focusing on inhibition of survival signal, Akt/PKB. A human oral cell cancer cell line B88 was used. Activation of Akt/PKB in vivo was examined by immunohistochemistry, and apoptotic cells were detected by TUNEL method. Activation of Akt/PKB in vitro was investigated by Western blot and ELISA, and apoptotic cells were detected by Hoechst 33258 staining. S-1 (10 mg/kg/day or 50 microg/ml) greatly enhanced radiosensitivity in B88 cells by suppressing the activation of Akt/PKB. Significant increase in the percentage of apoptotic cells was observed in S-1 treated B88 cells. Survival signals Akt/PKB may be involved in determining radiosensitivity. S-1, an oral fluoropyrimidine anti-cancer agent can exert the enhancing effect on radiation by suppressing the activation of Akt/PKB.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Oxonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Sensitizing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/S 1 (combination),
http://linkedlifedata.com/resource/pubmed/chemical/Tegafur
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
226
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-168
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16134238-Animals,
pubmed-meshheading:16134238-Antineoplastic Agents,
pubmed-meshheading:16134238-Apoptosis,
pubmed-meshheading:16134238-Blotting, Western,
pubmed-meshheading:16134238-Drug Combinations,
pubmed-meshheading:16134238-Enzyme Activation,
pubmed-meshheading:16134238-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16134238-Humans,
pubmed-meshheading:16134238-Immunohistochemistry,
pubmed-meshheading:16134238-In Situ Nick-End Labeling,
pubmed-meshheading:16134238-Male,
pubmed-meshheading:16134238-Mice,
pubmed-meshheading:16134238-Mice, Nude,
pubmed-meshheading:16134238-Mouth Neoplasms,
pubmed-meshheading:16134238-Oxonic Acid,
pubmed-meshheading:16134238-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16134238-Proto-Oncogene Proteins,
pubmed-meshheading:16134238-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16134238-Pyridines,
pubmed-meshheading:16134238-Radiation-Sensitizing Agents,
pubmed-meshheading:16134238-Tegafur
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pubmed:year |
2005
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pubmed:articleTitle |
S-1, an oral fluoropyrimidine anti-cancer agent, enhanced radiosensitivity in a human oral cancer cell line in vivo and in vitro: involvement possibility of inhibition of survival signal, Akt/PKB.
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pubmed:affiliation |
Second Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan. harako@dent.tokushima-u.ac.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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