Linked Life Data

16134176

Source:http://linkedlifedata.com/resource/pubmed/id/16134176

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-19
pubmed:abstractText
Foldable hydrogel films with micropatterns measuring 480 microm by 45 microm by 54 microm by 2 cm (width of microchannel by width of microwall by height of wall by length of pattern) were made by UV embossing of a block copolymer of polycaprolactone (PCL) and poly(ethylene glycol) (PEG), specifically PCL-b-PEG-b-PCL-diacrylate (DA), with a polydimethylsiloxane mold. The mold was treated with Ar/CF(4) plasma to simultaneously promote microchannel filling and demolding, and the glass substrate was modified with 3-(trimethoxysilyl) propyl acrylate to promote hydrogel adhesion to avoid delamination of the gel during demolding. The micropatterned hydrogel film was detached from the glass substrate by freeze-drying. As the films were demolded, the microstructured pattern was well replicated in the hydrogel. The gel pattern dimensions shrank with freeze-drying and increased with water swelling, but under both conditions, the gel micropattern morphology was perfectly preserved. PCL-b-PEG-b-PCL-DA hydrogel was found to have good biocompatibility compared with PEGDA hydrogel. A micropattern with a smaller microchannel width of 50 microm was also made. Micropatterned foldable and biocompatible hydrogel films have potential applications in the construction of tissue-engineering scaffolds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1552-4973
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Foldable micropatterned hydrogel film made from biocompatible PCL-b-PEG-b-PCL diacrylate by UV embossing.
pubmed:affiliation
School of Chemical and Biomedical Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't