Linked Life Data

16133982

Source:http://linkedlifedata.com/resource/pubmed/id/16133982

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-8-31
pubmed:abstractText
The entity of serrated adenoma of the colorectum was first proposed in 1990, and it was characterized as epithelial neoplasia combining the architectural features of a hyperplastic polyp with the cytological features of an adenoma. Over the past few years, various clinicopathological studies on serrated adenoma have been reported, but its histogenesis remains unclear. Recently the existence of a "serrated neoplasia pathway" leading to malignancy, which is different from the so-called adenoma-carcinoma sequence, has been discussed. Yao et al. reported that hyperplastic polyps and serrated adenomas share a common cell lineage with gastric differentiation. To clarify the existence of the serrated neoplasia pathway, we performed immunohistochemical staining of cytokeratin 7 (CK7) and cytokeratin 20 (CK20), which are commonly used to determine the primary site of a metastatic lesion, and we examined the pattern of CK7/CK20 expression in various colorectal lesions including 44 serrated adenomas, 25 hyperplastic polyps, 20 traditional adenomas, and 48 carcinomas. An obvious difference existed in the pattern of CK7/CK20 expression between the serrated lesions (hyperplastic polyps and serrated adenomas) and others. The majority of serrated adenomas and hyperplastic polyps presented a CK7+/CK20+ pattern, whereas most conventional adenomas and adenocarcinomas expressed CK7-/CK20+. Adenocarcinoma developing in serrated adenoma also presented a CK7+/CK20+ pattern. There are several reports that CK7 is a possible marker of transient dedifferentiation in the gastric carcinogenesis process. Taken together with the present results, a distinct pathway of colorectal carcinogenesis must exist, which is different from the adenoma-carcinoma sequence. CK7 is a possible marker for the serrated neoplasia pathway of colorectal carcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1741-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16133982-Adenocarcinoma, pubmed-meshheading:16133982-Adenoma, pubmed-meshheading:16133982-Adult, pubmed-meshheading:16133982-Aged, pubmed-meshheading:16133982-Aged, 80 and over, pubmed-meshheading:16133982-Cell Transformation, Neoplastic, pubmed-meshheading:16133982-Colonic Polyps, pubmed-meshheading:16133982-Colorectal Neoplasms, pubmed-meshheading:16133982-Female, pubmed-meshheading:16133982-Gene Expression Profiling, pubmed-meshheading:16133982-Humans, pubmed-meshheading:16133982-Immunohistochemistry, pubmed-meshheading:16133982-Intermediate Filament Proteins, pubmed-meshheading:16133982-Keratin-20, pubmed-meshheading:16133982-Keratin-7, pubmed-meshheading:16133982-Keratins, pubmed-meshheading:16133982-Male, pubmed-meshheading:16133982-Middle Aged, pubmed-meshheading:16133982-Tumor Markers, Biological
pubmed:year
2005
pubmed:articleTitle
Expression of cytokeratins 7 and 20 in serrated adenoma and related diseases.
pubmed:affiliation
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi-Hirokoji, Kamigyo-ku, Japan. tatsu725@belle.shiga-med.ac.jp
pubmed:publicationType
Journal Article, Comparative Study