16131607

Source:http://linkedlifedata.com/resource/pubmed/id/16131607

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001618, umls-concept:C0010192, umls-concept:C1514485, umls-concept:C1515655
pubmed:issue	3
pubmed:dateCreated	2005-8-31
pubmed:abstractText	Although several lines of evidence suggest that the overall effects of the ACTH receptor, melanocortin 2 receptor (MC2-R), mediated signal transduction on adrenocortical growth and tumorigenesis are anti-proliferative, activation of MC2-R induces mitogens like jun, fos, and myc and activates the MAPK pathway. In vivo, potential effects of endogenous ACTH on adrenal tumori-genesis can not be separated from effects of other POMC derived peptides.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9423848
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone, http://linkedlifedata.com/resource/pubmed/chemical/Cosyntropin, http://linkedlifedata.com/resource/pubmed/chemical/Delayed-Action Preparations, http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen, http://linkedlifedata.com/resource/pubmed/chemical/RNA, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 2
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0804-4643
pubmed:author	pubmed-author:BeuschleinFelixF, pubmed-author:ReinckeMartinM, pubmed-author:SchulteDominik MDM, pubmed-author:ZwermannOliverO
pubmed:issnType	Print
pubmed:volume	153
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	435-44
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16131607-Adrenal Cortex Neoplasms, pubmed-meshheading:16131607-Adrenocortical Hyperfunction, pubmed-meshheading:16131607-Animals, pubmed-meshheading:16131607-Cell Growth Processes, pubmed-meshheading:16131607-Cell Line, Tumor, pubmed-meshheading:16131607-Corticosterone, pubmed-meshheading:16131607-Cosyntropin, pubmed-meshheading:16131607-Delayed-Action Preparations, pubmed-meshheading:16131607-Female, pubmed-meshheading:16131607-Immunohistochemistry, pubmed-meshheading:16131607-In Situ Nick-End Labeling, pubmed-meshheading:16131607-Male, pubmed-meshheading:16131607-Mice, pubmed-meshheading:16131607-Organ Size, pubmed-meshheading:16131607-Proliferating Cell Nuclear Antigen, pubmed-meshheading:16131607-RNA, pubmed-meshheading:16131607-Receptor, Melanocortin, Type 2, pubmed-meshheading:16131607-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16131607-Transfection
pubmed:year	2005
pubmed:articleTitle	ACTH 1-24 inhibits proliferation of adrenocortical tumors in vivo.
pubmed:affiliation	Medizinische Klinik-Innenstadt, Ludwig Maximilians University, Munich, Germany.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't