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rdf:type |
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lifeskim:mentions |
umls-concept:C0029939,
umls-concept:C0033268,
umls-concept:C0086418,
umls-concept:C0439851,
umls-concept:C0441472,
umls-concept:C0597513,
umls-concept:C1149301,
umls-concept:C1257987,
umls-concept:C1280500,
umls-concept:C1552596,
umls-concept:C1947931
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pubmed:issue |
11
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pubmed:dateCreated |
2005-11-8
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pubmed:abstractText |
Hyperinsulinemia contributes to the pathogenesis of ovarian dysfunction in insulin-resistant states, including polycystic ovary syndrome (PCOS). Peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists [thiazolidinediones (TZDs)] ameliorate hyperandrogenism in polycystic ovary syndrome presumably because they reduce systemic hyperinsulinemia. Direct effects of TZDs in the ovary, however, cannot be excluded. We explored direct effects of TZDs in cultured human ovarian cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6099-105
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16131582-Adult,
pubmed-meshheading:16131582-Cells, Cultured,
pubmed-meshheading:16131582-Estradiol,
pubmed-meshheading:16131582-Female,
pubmed-meshheading:16131582-Gonadal Steroid Hormones,
pubmed-meshheading:16131582-Humans,
pubmed-meshheading:16131582-Insulin,
pubmed-meshheading:16131582-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:16131582-Middle Aged,
pubmed-meshheading:16131582-Ovary,
pubmed-meshheading:16131582-PPAR gamma,
pubmed-meshheading:16131582-Progesterone,
pubmed-meshheading:16131582-Testosterone,
pubmed-meshheading:16131582-Thiazolidinediones
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pubmed:year |
2005
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pubmed:articleTitle |
Direct thiazolidinedione action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 production.
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pubmed:affiliation |
Division of Endocrinology, Beth Israel Medical Center, 317 East 17th Street, Fierman Hall, Seventh Floor, New York, New York 10003, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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