Linked Life Data

16128908

Source:http://linkedlifedata.com/resource/pubmed/id/16128908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-8-30
pubmed:abstractText
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man. In addition, it has previously been reported that this D-amino acid appears to have pharmacological activity. The present work aimed at evaluating the toxicity and pharmacology of D-arginine administered by the intraperitoneally route in albino male mice. Toxicity of D-arginine, alone as well as in the presence of propranolol and betamethasone was evaluated. D-Arginine in mice showed a light toxicity order (DL50: 2800 mg/kg). Previous injection of the beta-adrenoceptor blocker, propranolol (2 mg/kg, intraperitoneally), or betamethasone (0.5 mg/kg, intraperitoneally) produced a decrease in the toxicity of D-arginine (LD50: 3600 mg/kg, 3300 mg/kg, respectively). Also, a neuropharmacological screening of D-arginine using behavioural, neurological, autonomic, barbiturate-induced sleep time and pentylenetetrazole-induced convulsions tests were performed. D-Arginine 700 mg/kg displayed central stimulant properties, whereas a depressant profile was observed at a dose of 1400 mg/kg. In addition, D-arginine 1400 mg/kg produced a potentiation of pentobarbital sleeping time and a marked anticonvulsivant action against pentylenetetrazole.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1742-7835
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16128908-Adrenergic beta-Antagonists, pubmed-meshheading:16128908-Animals, pubmed-meshheading:16128908-Arginine, pubmed-meshheading:16128908-Autonomic Nervous System, pubmed-meshheading:16128908-Behavior, Animal, pubmed-meshheading:16128908-Betamethasone, pubmed-meshheading:16128908-Central Nervous System, pubmed-meshheading:16128908-Dose-Response Relationship, Drug, pubmed-meshheading:16128908-Drug Interactions, pubmed-meshheading:16128908-Hypnotics and Sedatives, pubmed-meshheading:16128908-Male, pubmed-meshheading:16128908-Mice, pubmed-meshheading:16128908-Motor Activity, pubmed-meshheading:16128908-Pentylenetetrazole, pubmed-meshheading:16128908-Phenobarbital, pubmed-meshheading:16128908-Propranolol, pubmed-meshheading:16128908-Seizures, pubmed-meshheading:16128908-Sleep
pubmed:year
2005
pubmed:articleTitle
Toxicological and pharmacological effects of D-arginine.
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Spain. enavarro@ull.es
pubmed:publicationType
Journal Article, Comparative Study