Source:http://linkedlifedata.com/resource/pubmed/id/16128222
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-8-30
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| pubmed:abstractText |
Little is known about the long-term natural history of asthma and the long-term clinical and functional consequences in non-smoking patients. From a functional point of view, non-smoking asthmatic patients may have a significantly greater decline in forced expiratory volume in one second (FEV1) compared with non-asthmatic subjects and may develop chronic irreversible (fixed) airflow limitation. This has been related to the physiological consequences of chronic airway inflammation causing airway remodeling. However these lesions are all potentially reversible and there is little radiological evidence indicating lung destruction (pulmonary emphysema), which is potentially irreversible, in non-smoking asthmatics. Severe chronic respiratory failure is the major cause of mortality in patients with severe chronic lung diseases. Domiciliary long-term oxygen therapy (LTOT) is an accepted treatment for patients with severe chronic respiratory failure. Our reasoning, therefore, was that if asthma is a cause of severe chronic respiratory failure in non-smokers we should be able to find non-smoking asthmatics within a large population of patients on LTOT. The aim of our study (Asthma and Long-term Oxygen Therapy, "ALOT") was to investigate the prevalence of non-smoking asthmatics in patients on LTOT in a multi-centre, cross-sectional study.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1122-0643
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| pubmed:author |
pubmed-author:AdcockI MIM,
pubmed-author:ArasNN,
pubmed-author:BarneyP LPL,
pubmed-author:CaramoriGG,
pubmed-author:CiacciaAA,
pubmed-author:FabbriMM,
pubmed-author:FalconeFF,
pubmed-author:Fan ChungKK,
pubmed-author:FelisattiGG,
pubmed-author:PaioliDD,
pubmed-author:PappZZ,
pubmed-author:SeveringKK
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| pubmed:issnType |
Print
|
| pubmed:volume |
63
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
84-7
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| pubmed:dateRevised |
2010-3-24
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| pubmed:meshHeading |
pubmed-meshheading:16128222-Aged,
pubmed-meshheading:16128222-Asthma,
pubmed-meshheading:16128222-Carbon Dioxide,
pubmed-meshheading:16128222-Chronic Disease,
pubmed-meshheading:16128222-Cross-Sectional Studies,
pubmed-meshheading:16128222-Female,
pubmed-meshheading:16128222-Forced Expiratory Volume,
pubmed-meshheading:16128222-Home Care Services,
pubmed-meshheading:16128222-Humans,
pubmed-meshheading:16128222-Longitudinal Studies,
pubmed-meshheading:16128222-Male,
pubmed-meshheading:16128222-Oxygen,
pubmed-meshheading:16128222-Oxygen Inhalation Therapy,
pubmed-meshheading:16128222-Physical Examination,
pubmed-meshheading:16128222-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:16128222-Respiratory Insufficiency,
pubmed-meshheading:16128222-Smoking,
pubmed-meshheading:16128222-Total Lung Capacity,
pubmed-meshheading:16128222-Vital Capacity
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| pubmed:year |
2005
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| pubmed:articleTitle |
Asthma is not a common cause of severe chronic respiratory failure in non-smokers: ALOT study.
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| pubmed:affiliation |
Centro di Ricerca su Asma e BPCO, Università di Ferrara, Italy. crm@unife.it
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|