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pubmed-article:16127071pubmed:abstractTextWe conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.lld:pubmed
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pubmed-article:16127071pubmed:affiliationDepartment of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599-7435, USA. alker@unc.edulld:pubmed
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