Linked Life Data

16126385

Source:http://linkedlifedata.com/resource/pubmed/id/16126385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-10-7
pubmed:abstractText
There is broad agreement that cells reconfigure their microtubules through rapid bouts of assembly and disassembly, as described by the mechanism known as dynamic instability. However, many cell types have complex patterns of microtubule organization that are not entirely explicable by dynamic instability. There is growing evidence that microtubules can be moved into new patterns of organization by forces generated by molecular motor proteins. Studies on several cell types support a model called 'cut and run' in which long microtubules are stationary, but relatively short microtubules are mobile. In this model, cells mobilize their microtubules by severing them into short pieces, using enzymes such as katanin and spastin that break the lattice of the microtubule polymer. After being reorganized, the short microtubules can once again elongate and lose their mobility. Microtubule severing is also crucial for a variation of 'cut and run' in which the severed microtubules are reorganized by means of treadmilling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0962-8924
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
518-24
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Microtubules cut and run.
pubmed:affiliation
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA. pbaas@drexelmed.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural