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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-7-30
|
| pubmed:abstractText |
The human genome carries multiple copies of sequences related to endogenous retroviral genomes. We investigated the distribution of one of these sequences, HERV-A, in 24 human chromosomes by Southern analyses using DNAs from flow-sorted chromosomes or rodent cells carrying a single human chromosome. The results showed that HERV-A is distributed among all human chromosomes and that each chromosome has a specific Southern blot profile. The chromosome-specific pattern did not show significant polymorphism, except in a few cases, when the same chromosome obtained from different individuals was compared. These chromosome-specific Southern hybridization profiles may be useful for chromosome karyotyping. This would allow the integrity of human chromosomes in human-rodent somatic cell hybrids to be monitored without using conventional cytogenetic methods.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
461-4
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1612606-Animals,
pubmed-meshheading:1612606-Blotting, Southern,
pubmed-meshheading:1612606-Cell Line,
pubmed-meshheading:1612606-Chromosome Mapping,
pubmed-meshheading:1612606-Chromosomes, Human,
pubmed-meshheading:1612606-Continental Population Groups,
pubmed-meshheading:1612606-Cricetinae,
pubmed-meshheading:1612606-Cricetulus,
pubmed-meshheading:1612606-DNA, Viral,
pubmed-meshheading:1612606-DNA Fingerprinting,
pubmed-meshheading:1612606-Female,
pubmed-meshheading:1612606-Humans,
pubmed-meshheading:1612606-Hybrid Cells,
pubmed-meshheading:1612606-Male,
pubmed-meshheading:1612606-Mice,
pubmed-meshheading:1612606-Polymorphism, Genetic,
pubmed-meshheading:1612606-Proviruses,
pubmed-meshheading:1612606-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1612606-Retroviridae,
pubmed-meshheading:1612606-Virus Integration
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Banding profiles of LTR of human endogenous retrovirus HERV-A in 24 chromosomes in somatic cell hybrids.
|
| pubmed:affiliation |
Institute for Molecular and Cellular Biology, Osaka University, Japan.
|
| pubmed:publicationType |
Journal Article
|