Source:http://linkedlifedata.com/resource/pubmed/id/16125936
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2005-9-27
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pubmed:abstractText |
Nucleotide pyrophosphatase/phosphodiesterase (NPP)-type ectophosphodiesterases are found at the cell surface as type-I or type-II transmembrane proteins, but are also found extracellularly as secreted or shedded enzymes. They hydrolyze pyrophosphate or phosphodiester bonds in a variety of extracellular compounds including nucleotides, (lyso)phospholipids and choline phosphate esters. Despite their structurally related catalytic domain, each enzyme has well-defined substrate specificity. Catalysis by NPPs affects processes as diverse as cell proliferation and motility, angiogenesis, bone mineralization and digestion. In addition, there is emerging evidence for non-catalytic functions of NPPs in cell signaling. NPP-type ectophosphodiesterases are also implicated in the pathophysiology of cancer, insulin resistance and calcification diseases, and they hold great promise as easily accessible therapeutic targets.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0968-0004
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
542-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16125936-Animals,
pubmed-meshheading:16125936-Cell Movement,
pubmed-meshheading:16125936-Cell Proliferation,
pubmed-meshheading:16125936-Humans,
pubmed-meshheading:16125936-Neovascularization, Physiologic,
pubmed-meshheading:16125936-Phosphoric Diester Hydrolases,
pubmed-meshheading:16125936-Pyrophosphatases,
pubmed-meshheading:16125936-Signal Transduction,
pubmed-meshheading:16125936-Structure-Activity Relationship,
pubmed-meshheading:16125936-Substrate Specificity
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pubmed:year |
2005
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pubmed:articleTitle |
NPP-type ectophosphodiesterases: unity in diversity.
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pubmed:affiliation |
Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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