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rdf:type |
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lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0009462,
umls-concept:C0010068,
umls-concept:C0035647,
umls-concept:C0134835,
umls-concept:C0441889,
umls-concept:C0599755,
umls-concept:C0679646,
umls-concept:C0681842,
umls-concept:C0948008,
umls-concept:C1551358,
umls-concept:C1882417,
umls-concept:C2603343
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pubmed:issue |
1
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pubmed:dateCreated |
2006-4-3
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pubmed:abstractText |
Inflammation, characterized by the recruitment/adhesion of circulating leukocytes by cellular adhesion molecules, plays an important role in the pathogenesis of atherosclerosis. Genetic analyses of P-selectin, a key adhesion molecule in the progression of atherosclerosis, have provided conflicting results regarding the role of variation within the P-selectin gene and risk for heart disease. No studies have examined the association of this polymorphism with stroke. Therefore, we examined the association of the P-selectin Thr715Pro polymorphism with incident coronary heart disease (CHD) and ischemic stroke among 14595 participants in the prospective cohort of the Atherosclerosis Risk in Communities (ARIC) Study.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9150
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16125711-Alleles,
pubmed-meshheading:16125711-Biological Markers,
pubmed-meshheading:16125711-Coronary Artery Disease,
pubmed-meshheading:16125711-Disease Progression,
pubmed-meshheading:16125711-Female,
pubmed-meshheading:16125711-Follow-Up Studies,
pubmed-meshheading:16125711-Gene Frequency,
pubmed-meshheading:16125711-Genotype,
pubmed-meshheading:16125711-Humans,
pubmed-meshheading:16125711-Incidence,
pubmed-meshheading:16125711-Male,
pubmed-meshheading:16125711-Middle Aged,
pubmed-meshheading:16125711-P-Selectin,
pubmed-meshheading:16125711-Polymorphism, Genetic,
pubmed-meshheading:16125711-Prospective Studies,
pubmed-meshheading:16125711-Risk Factors,
pubmed-meshheading:16125711-Stroke,
pubmed-meshheading:16125711-United States
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pubmed:year |
2006
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pubmed:articleTitle |
P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.
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pubmed:affiliation |
Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr., Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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