Source:http://linkedlifedata.com/resource/pubmed/id/16125269
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-10-24
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| pubmed:abstractText |
In this study, alpha-cobrotoxin was incorporated into the microspheres composed of poly(lactide-co-glycolide) (PLGA) and poly[1,3-bis(p-carboxy-phenoxy) propane-co-p-(carboxyethylformamido) benzoic anhydride] (P(CPP:CEFB)) and intranasally delivered to model rats in order to improve its analgesic activity. The microspheres with high entrapment efficiency (>80%) and average diameter of about 25 microm could be prepared by a modified water-in-oil-in-oil (w/o/o) emulsion solvent evaporation method. Scanning electron micrograph (SEM) study indicated that P(CPP:CEFB) content played a considerable role on the morphology and degradation of the microspheres. The presence of P(CPP:CEFB) in the microspheres increased their residence time at the surface of the nasal rat mucosa. The toxicity of the composite microspheres to nasal mucosa was proved to be mild and reversible. A tail flick assay was used to evaluate the antinociceptive activity of the microspheres after nasal administration. Compared with the free alpha-cobrotoxin and PLGA microspheres, PLGA/P(CPP:CEFB) microspheres showed an apparent increase in the strength and duration of the antinociceptive effect at the same dose of alpha-cobrotoxin (80 microg/kg body weight).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0168-3659
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
2
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| pubmed:volume |
108
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
10-20
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16125269-Administration, Intranasal,
pubmed-meshheading:16125269-Analgesics, Non-Narcotic,
pubmed-meshheading:16125269-Animals,
pubmed-meshheading:16125269-Cobra Neurotoxin Proteins,
pubmed-meshheading:16125269-Drug Compounding,
pubmed-meshheading:16125269-Drug Delivery Systems,
pubmed-meshheading:16125269-Drug Stability,
pubmed-meshheading:16125269-Male,
pubmed-meshheading:16125269-Microspheres,
pubmed-meshheading:16125269-Nasal Mucosa,
pubmed-meshheading:16125269-Pain,
pubmed-meshheading:16125269-Polyglactin 910,
pubmed-meshheading:16125269-Rats,
pubmed-meshheading:16125269-Rats, Wistar,
pubmed-meshheading:16125269-Solubility,
pubmed-meshheading:16125269-Time Factors
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Preparation, characterization and nasal delivery of alpha-cobrotoxin-loaded poly(lactide-co-glycolide)/polyanhydride microspheres.
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| pubmed:affiliation |
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
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| pubmed:publicationType |
Journal Article
|