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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-9-5
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pubmed:abstractText |
Galanin (GAL) is a neuropeptide involved in pain transmission. Intraplantar GAL at low doses enhances capsaicin (CAP)-induced pain behaviors in rat, suggesting an excitatory role for GAL under acute inflammatory conditions. The mechanisms underlying this pro-nociceptive action have not yet been elucidated. Thus, the present study investigated the role of protein kinase C (PKC) in the GAL enhancement of CAP-induced inflammatory pain. Ipsilateral, but not contralateral, calphostin C, a PKC inhibitor, blocked GAL-induced potentiation of CAP-evoked inflammatory pain in a dose-dependent fashion. Peripheral activation of PKC using the phorbol ester phorbol-12-myristate-13-acetate (PMA) mimicked the pro-nociceptive effect of GAL. These results suggest that GAL enhances acute inflammatory pain through activation of PKC intracellular pathways.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
1056
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16125151-Animals,
pubmed-meshheading:16125151-Capsaicin,
pubmed-meshheading:16125151-Dose-Response Relationship, Drug,
pubmed-meshheading:16125151-Drug Interactions,
pubmed-meshheading:16125151-Enzyme Inhibitors,
pubmed-meshheading:16125151-Functional Laterality,
pubmed-meshheading:16125151-Galanin,
pubmed-meshheading:16125151-Inflammation,
pubmed-meshheading:16125151-Male,
pubmed-meshheading:16125151-Naphthalenes,
pubmed-meshheading:16125151-Pain,
pubmed-meshheading:16125151-Pain Measurement,
pubmed-meshheading:16125151-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:16125151-Protein Kinase C,
pubmed-meshheading:16125151-Rats,
pubmed-meshheading:16125151-Rats, Wistar,
pubmed-meshheading:16125151-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Mechanism by which peripheral galanin increases acute inflammatory pain.
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pubmed:affiliation |
Seccion Externa de Farmacologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico, D.F., Mexico.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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