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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-9-9
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pubmed:abstractText |
The contribution of plasma membrane-associated glucocorticoid receptor (GR) to transcriptional signaling is unclear. We observed GR in low-density detergent-resistant membrane (DRM) rafts derived from human hepatoma Hep3B cells in complexes with caveolin-1, HSP90, and STAT3. In transient transfection assays, GR-stimulated transcriptional signaling was reversibly inhibited by membrane-raft disrupters filipin III and progesterone. These data provide clear evidence for a functional contribution of DRM-associated GR to transcriptional signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
336
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16125141-Base Sequence,
pubmed-meshheading:16125141-Caveolin 1,
pubmed-meshheading:16125141-Caveolins,
pubmed-meshheading:16125141-Cell Line, Tumor,
pubmed-meshheading:16125141-Cell Membrane,
pubmed-meshheading:16125141-Filipin,
pubmed-meshheading:16125141-Humans,
pubmed-meshheading:16125141-Octoxynol,
pubmed-meshheading:16125141-Oligonucleotides,
pubmed-meshheading:16125141-Receptors, Glucocorticoid,
pubmed-meshheading:16125141-Signal Transduction,
pubmed-meshheading:16125141-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Transcriptional signaling from membrane raft-associated glucocorticoid receptor.
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pubmed:affiliation |
Department of Pathology, New York Medical College, Valhalla, NY 10595, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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