Linked Life Data

1612480

Source:http://linkedlifedata.com/resource/pubmed/id/1612480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-7-28
pubmed:abstractText
Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain. 'Steady state' perfusions (10 ml/minute) in 12 patients with acute cholera, and repeat perfusions in nine of these patients during the convalescent phase were therefore performed using the triple lumen technique. The proximal jejunum was perfused with isotonic saline containing sodium-sulphobromophthalein as a non-absorbable marker. After intravenous administration of indomethacin (1.0 mg/kg) the jejunal net transfer of fluid and the jejunal flow rate of PGE2 were determined in 30 minute periods for 120 minutes after a 120 minute control period. Indomethacin decreased net fluid secretion (2.1 (0.3-4.2) v 4.5 (2.5-8.4) ml/hour x cm; medians, Q50 ranges, p less than 0.01) and the jejunal flow rate of PGE2 (1.5 (1.2-2.7) v 2.2 (1.4-4.9) ng/minute, p less than 0.05). The results of similar perfusion studies in 22 patients with acute cholera, used to establish the spontaneous time related change in fluid secretion, showed no significant change in net fluid transfer (3.5 (2.2-6.2) to 3.5 (2.6-11.6) ml/hour x cm, p greater than 0.25) over 240 minutes. These data provide further evidence in favour of the hypothesis that prostaglandins have a role in the cholera toxin induced intestinal fluid secretion in man.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-186352, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-2535994, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-3197980, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-3855402, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-3899840, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-4551226, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-4606663, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-4729203, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-4933002, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-5409804, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-5900951, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-6477537, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-6573927, http://linkedlifedata.com/resource/pubmed/commentcorrection/1612480-6791938
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera.
pubmed:affiliation
International Centre for Diarrhoeal Disease Research, Bangladesh.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't